Author: aussies

Multidrug Sensitivity in Herding Breeds: MDR1 Gene Mutation

MDR1 Gene Mutation: The MDR1 gene encodes P-glycoprotein, a drug transport pump that plays an important role in limiting drug absorption and distribution (particularly to the brain), as well as enhancing the excretion of many drugs used in dogs. Some dogs, particularly herding breeds, have a mutation in the MDR1 gene, leaving them defective in their ability to limit drug absorption and distribution. These dogs also have delayed excretion of drugs that are normally transported by P-glycoprotein. Drugs Affected by the MDR1 Gene Mutation: Acepromazine Butorphanol Doxorubicin Erythromycin Ivermectin Loperamide Milbemycin Moxidectin Rifampin Selamectin Vinblastine Vincristine Breeds affected by the MDR1 mutation (frequency %) Breed Approximate Frequency Australian Shepherd 50% Australian Shepherd, Mini 50% Border Collie < 5% Collie 70 % English Shepherd 15 % German Shepherd 10 % Herding Breed Cross 10 % Long-haired Whippet 65 % McNab 30 % Mixed Breed 5 % Old English Sheepdog 5 % Shetland Sheepdog 15 % Silken Windhound 30 % Testing a Dog for the MDR1 Mutation is Easy: Order a testing kit by contacting the Veterinary Clinical Pharmacology Laboratory at Washington State University: or by phone 509-335-3745...

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Our new latest edition to Aussie Meetup. Is Jasper a Red Merle of 4months old. He is adorable. Belle approves and is rock 'n roll in his...

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Hello Aussie Lovers

Aussie Meetup is for Australian Shepherd parents to find each other around the globe so your furry kids can play together. Also Aussie meet up is for Australian Shepherd parents to get involved in different groups and topics so others can understand this amazing breed. To become a part of Aussie Meetup you must first register as a member. The memberships are free. After you have registered you will be approved and then you can login in and become part of our global Aussie...

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